Drug interactions
Perindopril + Promazine
Severity: Moderate
Perindopril and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension and may add to the blood pressure lowering effect of perindopril. This may lead to dizziness and falls, particularly in older patients.
What this interaction means in plain words
Perindopril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from phenothiazine alpha-blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when combining, and reduce the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Promazine?
MediHelp rates the interaction as moderate. Perindopril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine, a phenothiazine with alpha-adrenergic blocking activity, can cause orthostatic hypotension and may add to the blood pressure lowering effect of perindopril. This may lead to dizziness and falls, particularly in older patients.
How serious is the interaction between Perindopril and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when combining, and reduce the dose of either drug if hypotension occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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