Drug interactions
Perindopril + Salicylates
Severity: Minor
Perindopril and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates given at anti-inflammatory doses may reduce the antihypertensive effect of ACE inhibitors and impair renal function in vulnerable patients. The effect is generally smaller than with other NSAIDs.
What this interaction means in plain words
Perindopril and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of renal prostaglandin synthesis opposes ACE inhibitor effects on vascular tone and renal perfusion.
What to do
Monitor blood pressure and renal function if high-dose salicylates are used long term, and ensure adequate hydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Salicylates?
MediHelp rates the interaction as minor. Perindopril and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-acetylated salicylates given at anti-inflammatory doses may reduce the antihypertensive effect of ACE inhibitors and impair renal function in vulnerable patients. The effect is generally smaller than with other NSAIDs.
How serious is the interaction between Perindopril and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if high-dose salicylates are used long term, and ensure adequate hydration.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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