Drug interactions
Perindopril + Salsalate
Severity: Moderate
Perindopril and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate may reduce the blood pressure lowering effect of perindopril and can contribute to decline in renal function in susceptible patients. The effect is typically smaller than with other NSAIDs.
What this interaction means in plain words
Perindopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium after starting salsalate, and keep patients well hydrated. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Salsalate?
MediHelp rates the interaction as moderate. Perindopril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate may reduce the blood pressure lowering effect of perindopril and can contribute to decline in renal function in susceptible patients. The effect is typically smaller than with other NSAIDs.
How serious is the interaction between Perindopril and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting salsalate, and keep patients well hydrated. Consider paracetamol as an alternative.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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