Drug interactions
Perindopril + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid and electrolyte shifts and volume depletion. With perindopril, this raises the risk of acute kidney injury, hypotension and electrolyte disturbances.
What this interaction means in plain words
Perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume depletion and electrolyte changes combine with ACE inhibitor effects on glomerular filtration and potassium handling.
What to do
Ensure adequate hydration and consider withholding perindopril on the day of bowel preparation. Check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid and electrolyte shifts and volume depletion. With perindopril, this raises the risk of acute kidney injury, hypotension and electrolyte disturbances.
How serious is the interaction between Perindopril and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding perindopril on the day of bowel preparation. Check renal function and electrolytes in high-risk patients.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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