Drug interactions
Perindopril + Synthetic human angiotensin ii
Severity: Moderate
Perindopril and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perindopril blocks conversion of angiotensin I to angiotensin II, so patients on ACE inhibitors may respond more strongly to exogenous angiotensin II. The pressor response can be exaggerated, though this is also exploited in vasodilatory shock.
What this interaction means in plain words
Perindopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition lowers endogenous angiotensin II, which can increase sensitivity to the exogenous peptide.
What to do
Start angiotensin II at the lowest dose and titrate to blood pressure with continuous monitoring. Be aware of the higher risk of an exaggerated pressor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Perindopril and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perindopril blocks conversion of angiotensin I to angiotensin II, so patients on ACE inhibitors may respond more strongly to exogenous angiotensin II. The pressor response can be exaggerated, though this is also exploited in vasodilatory shock.
How serious is the interaction between Perindopril and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the lowest dose and titrate to blood pressure with continuous monitoring. Be aware of the higher risk of an exaggerated pressor response.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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