Drug interactions
Perindopril + Xipamide
Severity: Moderate
Perindopril and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering of perindopril. First-dose hypotension, volume depletion and electrolyte or renal disturbances can occur.
What this interaction means in plain words
Perindopril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from diuresis-driven volume depletion and renin-angiotensin blockade.
What to do
Monitor blood pressure, renal function and electrolytes when starting. Consider reducing the diuretic dose or temporarily withholding it before starting perindopril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Xipamide?
MediHelp rates the interaction as moderate. Perindopril and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering of perindopril. First-dose hypotension, volume depletion and electrolyte or renal disturbances can occur.
How serious is the interaction between Perindopril and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes when starting. Consider reducing the diuretic dose or temporarily withholding it before starting perindopril in volume-depleted patients.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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