Drug interactions
Phendimetrazine + Pirbuterol
Severity: Moderate
Phendimetrazine and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic and adds to the cardiovascular stimulation of pirbuterol. This may cause tachycardia, palpitations, raised blood pressure, tremor and nervousness.
What this interaction means in plain words
Phendimetrazine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects through direct beta-agonism and indirect catecholamine release.
What to do
Monitor heart rate and blood pressure, and reduce or stop one agent if cardiovascular symptoms occur. Avoid in patients with significant cardiac disease or uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Phendimetrazine and Pirbuterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Phendimetrazine with Pirbuterol?
MediHelp rates the interaction as moderate. Phendimetrazine and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic and adds to the cardiovascular stimulation of pirbuterol. This may cause tachycardia, palpitations, raised blood pressure, tremor and nervousness.
How serious is the interaction between Phendimetrazine and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce or stop one agent if cardiovascular symptoms occur. Avoid in patients with significant cardiac disease or uncontrolled hypertension.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
