Drug interactions
Phendimetrazine + Terbutaline
Severity: Moderate
Phendimetrazine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic and terbutaline is a beta-2 agonist, so combined use can increase heart rate, blood pressure, tremor, nervousness and palpitations. Patients with cardiovascular disease or hyperthyroidism are at particular risk.
What this interaction means in plain words
Phendimetrazine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic effects from indirect (releasing) and direct beta-agonist actions.
What to do
Monitor heart rate and blood pressure and watch for palpitations or arrhythmia. Consider alternatives to the anorectic in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Phendimetrazine with Terbutaline?
MediHelp rates the interaction as moderate. Phendimetrazine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic anorectic and terbutaline is a beta-2 agonist, so combined use can increase heart rate, blood pressure, tremor, nervousness and palpitations. Patients with cardiovascular disease or hyperthyroidism are at particular risk.
How serious is the interaction between Phendimetrazine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and watch for palpitations or arrhythmia. Consider alternatives to the anorectic in patients with cardiac disease.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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