Drug interactions
Phenoxybenzamine + Salbutamol
Severity: Moderate
Phenoxybenzamine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine irreversibly blocks alpha-adrenoceptors, so beta-2 vasodilation from salbutamol is unopposed and can lower blood pressure further. This may cause hypotension with reflex tachycardia.
What this interaction means in plain words
Phenoxybenzamine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha blockade unmasks beta-2 mediated vasodilation, with additive hypotension and reflex tachycardia.
What to do
Monitor blood pressure and heart rate when starting or increasing salbutamol, particularly with systemic or high-dose use. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Phenoxybenzamine with Salbutamol?
MediHelp rates the interaction as moderate. Phenoxybenzamine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine irreversibly blocks alpha-adrenoceptors, so beta-2 vasodilation from salbutamol is unopposed and can lower blood pressure further. This may cause hypotension with reflex tachycardia.
How serious is the interaction between Phenoxybenzamine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or increasing salbutamol, particularly with systemic or high-dose use. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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