Drug interactions
Phenoxybenzamine + Terbutaline
Severity: Moderate
Phenoxybenzamine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine blocks alpha-1 receptors, while terbutaline causes beta-2 mediated vasodilation. Combined, peripheral vasodilation can produce hypotension with reflex tachycardia, and the alpha blockade leaves beta effects unopposed.
What this interaction means in plain words
Phenoxybenzamine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade combined with beta-2 mediated vasodilation leads to additive hypotension and reflex tachycardia.
What to do
Monitor blood pressure and heart rate, particularly after dose changes or starting terbutaline. Counsel patients on orthostatic symptoms and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Phenoxybenzamine with Terbutaline?
MediHelp rates the interaction as moderate. Phenoxybenzamine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine blocks alpha-1 receptors, while terbutaline causes beta-2 mediated vasodilation. Combined, peripheral vasodilation can produce hypotension with reflex tachycardia, and the alpha blockade leaves beta effects unopposed.
How serious is the interaction between Phenoxybenzamine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly after dose changes or starting terbutaline. Counsel patients on orthostatic symptoms and adjust doses as needed.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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