Drug interactions
Phenytoin + Rabeprazole
Severity: Minor
Phenytoin and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP2C19 and CYP3A4, which play a limited role in rabeprazole clearance, so rabeprazole levels may fall. Rabeprazole may also slightly affect phenytoin levels, but evidence is limited.
What this interaction means in plain words
Phenytoin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phenytoin belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Phenytoin enzyme induction increases rabeprazole metabolism.
What to do
No routine change is needed; monitor acid-related symptoms and phenytoin levels if the clinical picture changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Phenytoin with Rabeprazole?
MediHelp rates the interaction as minor. Phenytoin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP2C19 and CYP3A4, which play a limited role in rabeprazole clearance, so rabeprazole levels may fall. Rabeprazole may also slightly affect phenytoin levels, but evidence is limited.
How serious is the interaction between Phenytoin and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor acid-related symptoms and phenytoin levels if the clinical picture changes.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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