Drug interactions
Phenytoin + Somatropin
Severity: Minor
Phenytoin and Somatropin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity, so clearance of CYP substrates such as phenytoin could rise and levels could fall. Published data are limited, and the clinical effect is probably small.
What this interaction means in plain words
Phenytoin and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Phenytoin belongs to Central Nervous System; Somatropin belongs to Endocrine.
Why it happens
Somatropin may induce CYP450-mediated metabolism, as suggested by increased antipyrine clearance.
What to do
Watch seizure control after starting or changing somatropin, and measure phenytoin levels if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Phenytoin with Somatropin?
MediHelp rates the interaction as minor. Phenytoin and Somatropin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Growth hormone may increase CYP450 activity, so clearance of CYP substrates such as phenytoin could rise and levels could fall. Published data are limited, and the clinical effect is probably small.
How serious is the interaction between Phenytoin and Somatropin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch seizure control after starting or changing somatropin, and measure phenytoin levels if control worsens.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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