Drug interactions
Phenytoin + Valoctocogene roxaparvovec
Severity: Moderate
Phenytoin and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes transaminase elevations, and hepatotoxic drugs may add to this risk. Phenytoin can cause liver injury, and enzyme inducers may also affect the gene therapy's efficacy.
What this interaction means in plain words
Phenytoin and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Phenytoin belongs to Central Nervous System; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential; phenytoin's enzyme induction may also affect transgene expression, though this is not well established.
What to do
Monitor liver enzymes closely as per gene therapy protocol, and consider an alternative antiseizure drug with less hepatotoxic potential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Phenytoin with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Phenytoin and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes transaminase elevations, and hepatotoxic drugs may add to this risk. Phenytoin can cause liver injury, and enzyme inducers may also affect the gene therapy's efficacy.
How serious is the interaction between Phenytoin and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely as per gene therapy protocol, and consider an alternative antiseizure drug with less hepatotoxic potential.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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