Drug interactions
Phenytoin + Vindesine
Severity: Moderate
Phenytoin and Vindesine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower exposure to vinca alkaloids such as vindesine, potentially reducing efficacy. Combination chemotherapy may also reduce phenytoin levels and cause breakthrough seizures.
What this interaction means in plain words
Phenytoin and Vindesine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenytoin induces CYP3A4 metabolism of vinca alkaloids; chemotherapy may reduce phenytoin absorption and alter its concentrations.
What to do
Monitor serum phenytoin concentrations and seizure control during chemotherapy and adjust the dose accordingly. Consider a non-inducing antiseizure drug as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Phenytoin with Vindesine?
MediHelp rates the interaction as moderate. Phenytoin and Vindesine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP3A4 and may lower exposure to vinca alkaloids such as vindesine, potentially reducing efficacy. Combination chemotherapy may also reduce phenytoin levels and cause breakthrough seizures.
How serious is the interaction between Phenytoin and Vindesine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum phenytoin concentrations and seizure control during chemotherapy and adjust the dose accordingly. Consider a non-inducing antiseizure drug as an alternative.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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