Drug interactions
Pholcodine + Pimozide
Severity: Minor
Pholcodine and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pholcodine is an opioid antitussive, and with pimozide it may add to drowsiness and psychomotor impairment. The effect is usually modest at antitussive doses.
What this interaction means in plain words
Pholcodine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects.
What to do
Advise patients about possible drowsiness and to avoid driving or alcohol until response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pholcodine with Pimozide?
MediHelp rates the interaction as minor. Pholcodine and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pholcodine is an opioid antitussive, and with pimozide it may add to drowsiness and psychomotor impairment. The effect is usually modest at antitussive doses.
How serious is the interaction between Pholcodine and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about possible drowsiness and to avoid driving or alcohol until response is known.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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