Drug interactions
Pholcodine + Triprolidine
Severity: Moderate
Pholcodine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, so together they may increase sedation and impair psychomotor performance. The effect is usually modest at standard doses but matters for driving and for older patients.
What this interaction means in plain words
Pholcodine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from a sedating first-generation antihistamine and an opioid antitussive.
What to do
Advise patients to avoid driving and alcohol while taking both. Use the lowest effective doses and watch older patients for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Frequently asked questions
Can I take Pholcodine with Triprolidine?
MediHelp rates the interaction as moderate. Pholcodine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness, so together they may increase sedation and impair psychomotor performance. The effect is usually modest at standard doses but matters for driving and for older patients.
How serious is the interaction between Pholcodine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol while taking both. Use the lowest effective doses and watch older patients for excess sedation.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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