Drug interactions
Pimozide + Procainamide
Severity: Contraindicated
Pimozide and Procainamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong ventricular repolarization, and procainamide is a known cause of torsades de pointes. Combined use markedly increases arrhythmic risk.
What this interaction means in plain words
Pimozide and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Do not use together. Choose an antiarrhythmic without QT effect or an alternative to pimozide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Procainamide?
MediHelp rates the interaction as contraindicated. Pimozide and Procainamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong ventricular repolarization, and procainamide is a known cause of torsades de pointes. Combined use markedly increases arrhythmic risk.
How serious is the interaction between Pimozide and Procainamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose an antiarrhythmic without QT effect or an alternative to pimozide.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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