Drug interactions
Pimozide + Promazine
Severity: Contraindicated
Pimozide and Promazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both phenothiazine-type and diphenylbutylpiperidine antipsychotics can prolong the QT interval. Combining them increases the risk of ventricular arrhythmia including torsades de pointes.
What this interaction means in plain words
Pimozide and Promazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination. Use a single antipsychotic and check ECG and electrolytes if therapy is changed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Promazine?
MediHelp rates the interaction as contraindicated. Pimozide and Promazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both phenothiazine-type and diphenylbutylpiperidine antipsychotics can prolong the QT interval. Combining them increases the risk of ventricular arrhythmia including torsades de pointes.
How serious is the interaction between Pimozide and Promazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a single antipsychotic and check ECG and electrolytes if therapy is changed.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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