Drug interactions
Pimozide + Quinupristin / dalfopristin
Severity: Contraindicated
Pimozide and Quinupristin / dalfopristin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and can raise pimozide concentrations, and it may itself affect QT. The combination can lead to dangerous arrhythmias.
What this interaction means in plain words
Pimozide and Quinupristin / dalfopristin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
CYP3A4 inhibition reduces pimozide clearance, with possible additive QT prolongation.
What to do
Avoid; use a different antibiotic for the infection.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Quinupristin / dalfopristin?
MediHelp rates the interaction as contraindicated. Pimozide and Quinupristin / dalfopristin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Quinupristin/dalfopristin inhibits CYP3A4 and can raise pimozide concentrations, and it may itself affect QT. The combination can lead to dangerous arrhythmias.
How serious is the interaction between Pimozide and Quinupristin / dalfopristin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use a different antibiotic for the infection.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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