Drug interactions
Pimozide + Remimazolam
Severity: Moderate
Pimozide and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a sedative benzodiazepine with an antipsychotic can produce additive sedation, hypotension and respiratory depression. Pimozide also prolongs QT, which matters in procedural settings with other risk factors.
What this interaction means in plain words
Pimozide and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by remimazolam and central dopamine blockade by pimozide.
What to do
Titrate remimazolam carefully and continuously monitor respiration, oxygen saturation and blood pressure. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Pimozide with Remimazolam?
MediHelp rates the interaction as moderate. Pimozide and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a sedative benzodiazepine with an antipsychotic can produce additive sedation, hypotension and respiratory depression. Pimozide also prolongs QT, which matters in procedural settings with other risk factors.
How serious is the interaction between Pimozide and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully and continuously monitor respiration, oxygen saturation and blood pressure. Have airway support available.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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