Drug interactions
Pimozide + Telotristat ethyl
Severity: Minor
Pimozide and Telotristat ethyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl may induce CYP3A4 and lower pimozide exposure, which could reduce antipsychotic or anti-tic efficacy. The effect is predicted from the mechanism rather than well characterised for pimozide specifically.
What this interaction means in plain words
Pimozide and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by telotristat ethyl may increase the metabolism of pimozide.
What to do
Monitor tic control and clinical response when telotristat is started or stopped. Adjust the pimozide dose only if efficacy is lost, with ECG monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Telotristat ethyl?
MediHelp rates the interaction as minor. Pimozide and Telotristat ethyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat ethyl may induce CYP3A4 and lower pimozide exposure, which could reduce antipsychotic or anti-tic efficacy. The effect is predicted from the mechanism rather than well characterised for pimozide specifically.
How serious is the interaction between Pimozide and Telotristat ethyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tic control and clinical response when telotristat is started or stopped. Adjust the pimozide dose only if efficacy is lost, with ECG monitoring.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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