Drug interactions
Pimozide + Thiothixene
Severity: Major
Pimozide and Thiothixene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two dopamine-blocking antipsychotics together raise the risk of extrapyramidal symptoms, tardive dyskinesia, sedation and neuroleptic malignant syndrome. Both can also prolong the QT interval, adding to arrhythmia risk.
What this interaction means in plain words
Pimozide and Thiothixene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive dopamine D2 antagonism, with additive sedation and QT effects.
What to do
Avoid concurrent antipsychotics where possible. If both are needed, use the lowest doses, obtain an ECG and monitor for movement disorders and rigidity or hyperthermia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Thiothixene?
MediHelp rates the interaction as major. Pimozide and Thiothixene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two dopamine-blocking antipsychotics together raise the risk of extrapyramidal symptoms, tardive dyskinesia, sedation and neuroleptic malignant syndrome. Both can also prolong the QT interval, adding to arrhythmia risk.
How serious is the interaction between Pimozide and Thiothixene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent antipsychotics where possible. If both are needed, use the lowest doses, obtain an ECG and monitor for movement disorders and rigidity or hyperthermia.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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