Drug interactions
Pimozide + Triazolam
Severity: Moderate
Pimozide and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide and triazolam both cause sedation, and combined use can lead to marked drowsiness and impaired coordination. Triazolam is also a sensitive CYP3A4 substrate, so any CYP3A4 effects can amplify its action.
What this interaction means in plain words
Pimozide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective triazolam dose and monitor sedation. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Triazolam?
MediHelp rates the interaction as moderate. Pimozide and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide and triazolam both cause sedation, and combined use can lead to marked drowsiness and impaired coordination. Triazolam is also a sensitive CYP3A4 substrate, so any CYP3A4 effects can amplify its action.
How serious is the interaction between Pimozide and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor sedation. Counsel patients to avoid driving and alcohol.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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