Drug interactions
Pimozide + Triprolidine
Severity: Moderate
Pimozide and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and together they may increase drowsiness and impaired alertness. Additive anticholinergic effects are also possible.
What this interaction means in plain words
Pimozide and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pimozide belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Counsel about sedation and avoid driving until the response is known. Use a non-sedating antihistamine if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Triprolidine?
MediHelp rates the interaction as moderate. Pimozide and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and together they may increase drowsiness and impaired alertness. Additive anticholinergic effects are also possible.
How serious is the interaction between Pimozide and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and avoid driving until the response is known. Use a non-sedating antihistamine if one is needed.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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