Drug interactions
Pimozide + Turmeric
Severity: Moderate
Pimozide and Turmeric: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Curcumin in turmeric may inhibit CYP3A4 in vitro, which could raise pimozide exposure. Clinical evidence is limited, and the effect from dietary amounts is probably small, though supplements may matter more.
What this interaction means in plain words
Pimozide and Turmeric can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP3A4 by curcumin reduces pimozide metabolism.
What to do
Advise against high-dose turmeric or curcumin supplements during pimozide therapy. Monitor for QT prolongation and adverse effects if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Turmeric?
MediHelp rates the interaction as moderate. Pimozide and Turmeric can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Curcumin in turmeric may inhibit CYP3A4 in vitro, which could raise pimozide exposure. Clinical evidence is limited, and the effect from dietary amounts is probably small, though supplements may matter more.
How serious is the interaction between Pimozide and Turmeric?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against high-dose turmeric or curcumin supplements during pimozide therapy. Monitor for QT prolongation and adverse effects if they are used.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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