Drug interactions
Pimozide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Pimozide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachycardia, which may add to the QT effect of pimozide. Systemic exposure from inhalation is low, but risk exists in susceptible patients.
What this interaction means in plain words
Pimozide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects.
What to do
Monitor ECG and symptoms such as palpitations, and keep potassium normal. Consider alternatives in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Pimozide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachycardia, which may add to the QT effect of pimozide. Systemic exposure from inhalation is low, but risk exists in susceptible patients.
How serious is the interaction between Pimozide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and symptoms such as palpitations, and keep potassium normal. Consider alternatives in patients with other QT risk factors.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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