Drug interactions
Pimozide + Yohimbine
Severity: Moderate
Pimozide and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that raises sympathetic activity and may oppose pimozide's sedation. It can cause anxiety, tachycardia and hypertension, and may counteract or complicate the effects of antipsychotic therapy.
What this interaction means in plain words
Pimozide and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition through central alpha-2 blockade and increased noradrenergic activity.
What to do
Avoid yohimbine in patients on pimozide where possible. If it is used, monitor heart rate, blood pressure, anxiety and psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Pimozide with Yohimbine?
MediHelp rates the interaction as moderate. Pimozide and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that raises sympathetic activity and may oppose pimozide's sedation. It can cause anxiety, tachycardia and hypertension, and may counteract or complicate the effects of antipsychotic therapy.
How serious is the interaction between Pimozide and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients on pimozide where possible. If it is used, monitor heart rate, blood pressure, anxiety and psychiatric symptoms.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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