Drug interactions
Pindolol + Prazosin
Severity: Moderate
Pindolol and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs have additive blood pressure lowering effects, which may cause first-dose or orthostatic hypotension. The combination is often used deliberately but needs careful titration.
What this interaction means in plain words
Pindolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from alpha-1 blockade and beta blockade.
What to do
Start prazosin at a low dose and increase gradually while monitoring standing blood pressure. Counsel the patient to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Pindolol with Prazosin?
MediHelp rates the interaction as moderate. Pindolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these drugs have additive blood pressure lowering effects, which may cause first-dose or orthostatic hypotension. The combination is often used deliberately but needs careful titration.
How serious is the interaction between Pindolol and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start prazosin at a low dose and increase gradually while monitoring standing blood pressure. Counsel the patient to rise slowly.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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