Drug interactions
Pindolol + Propranolol
Severity: Major
Pindolol and Propranolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two beta-blockers together duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Pindolol's intrinsic sympathomimetic activity may also partly counteract propranolol.
What this interaction means in plain words
Pindolol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta-adrenergic blockade, with a partial agonist effect from pindolol.
What to do
Avoid combining systemic beta-blockers; use a single agent. Monitor heart rate and blood pressure if both must be used briefly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Pindolol with Propranolol?
MediHelp rates the interaction as major. Pindolol and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two beta-blockers together duplicates therapy and increases the risk of bradycardia, hypotension and AV block. Pindolol's intrinsic sympathomimetic activity may also partly counteract propranolol.
How serious is the interaction between Pindolol and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining systemic beta-blockers; use a single agent. Monitor heart rate and blood pressure if both must be used briefly.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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