Drug interactions
Pindolol + Salbutamol
Severity: Major
Pindolol and Salbutamol: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is a non-selective beta-blocker with partial agonist activity that can antagonize salbutamol and cause bronchospasm in patients with asthma or COPD. Salbutamol may then be less effective as reliever therapy.
What this interaction means in plain words
Pindolol and Salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenoceptors.
What to do
Avoid pindolol in patients with asthma or reversible airway disease and use an alternative antihypertensive. If it cannot be avoided, monitor respiratory status closely and expect a reduced response to salbutamol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Salbutamol
Frequently asked questions
Can I take Pindolol with Salbutamol?
MediHelp rates the interaction as major. Pindolol and Salbutamol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pindolol is a non-selective beta-blocker with partial agonist activity that can antagonize salbutamol and cause bronchospasm in patients with asthma or COPD. Salbutamol may then be less effective as reliever therapy.
How serious is the interaction between Pindolol and Salbutamol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pindolol in patients with asthma or reversible airway disease and use an alternative antihypertensive. If it cannot be avoided, monitor respiratory status closely and expect a reduced response to salbutamol.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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