Drug interactions
Pirbuterol + Yohimbine
Severity: Moderate
Pirbuterol and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity, so using them together can add to increases in heart rate and blood pressure and may provoke palpitations, tremor or anxiety. Patients with cardiovascular disease or arrhythmia are most at risk.
What this interaction means in plain words
Pirbuterol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation: pirbuterol is a beta2-agonist and yohimbine is an alpha2-antagonist that raises noradrenergic outflow.
What to do
Monitor heart rate, blood pressure and symptoms of adrenergic excess when the two are used together. Avoid yohimbine in patients with significant cardiovascular disease or uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Pirbuterol with Yohimbine?
MediHelp rates the interaction as moderate. Pirbuterol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity, so using them together can add to increases in heart rate and blood pressure and may provoke palpitations, tremor or anxiety. Patients with cardiovascular disease or arrhythmia are most at risk.
How serious is the interaction between Pirbuterol and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and symptoms of adrenergic excess when the two are used together. Avoid yohimbine in patients with significant cardiovascular disease or uncontrolled hypertension.
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