Drug interactions
Pitavastatin + Ponatinib
Severity: Moderate
Pitavastatin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may inhibit OATP1B1 or BCRP and raise pitavastatin exposure. This could raise the risk of muscle toxicity.
What this interaction means in plain words
Pitavastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pitavastatin belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Ponatinib may inhibit hepatic and intestinal transporters (OATP1B1, BCRP), increasing pitavastatin exposure.
What to do
Use the lowest effective pitavastatin dose and monitor for myalgia. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pitavastatin and Ponatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pitavastatin
Other interactions of Ponatinib
Frequently asked questions
Can I take Pitavastatin with Ponatinib?
MediHelp rates the interaction as moderate. Pitavastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib may inhibit OATP1B1 or BCRP and raise pitavastatin exposure. This could raise the risk of muscle toxicity.
How serious is the interaction between Pitavastatin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective pitavastatin dose and monitor for myalgia. Check CK if symptoms occur.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
