Drug interactions
Pitavastatin + Sofosbuvir / velpatasvir
Severity: Major
Pitavastatin and Sofosbuvir / velpatasvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir can substantially increase pitavastatin concentrations, raising the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Pitavastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1, decreasing hepatic uptake of pitavastatin.
What to do
Avoid the combination or suspend pitavastatin during HCV treatment. If used, give the lowest dose and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Pitavastatin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Pitavastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir can substantially increase pitavastatin concentrations, raising the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Pitavastatin and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or suspend pitavastatin during HCV treatment. If used, give the lowest dose and monitor for muscle symptoms.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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