Drug interactions
Pitavastatin + Tafamidis meglumine
Severity: Moderate
Pitavastatin and Tafamidis meglumine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis meglumine inhibits BCRP and may raise exposure to BCRP substrates such as pitavastatin. The clinical effect is probably modest but could raise the risk of statin muscle effects.
What this interaction means in plain words
Pitavastatin and Tafamidis meglumine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tafamidis inhibits BCRP efflux, which may increase pitavastatin exposure.
What to do
Monitor for myalgia or weakness and use the lowest effective pitavastatin dose. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Pitavastatin with Tafamidis meglumine?
MediHelp rates the interaction as moderate. Pitavastatin and Tafamidis meglumine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tafamidis meglumine inhibits BCRP and may raise exposure to BCRP substrates such as pitavastatin. The clinical effect is probably modest but could raise the risk of statin muscle effects.
How serious is the interaction between Pitavastatin and Tafamidis meglumine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia or weakness and use the lowest effective pitavastatin dose. Check CK if symptoms develop.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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