Drug interactions
Pitavastatin + Telmisartan-amlodipine
Severity: Minor
Pitavastatin and Telmisartan-amlodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan has been described as an OATP1B1 inhibitor in vitro, which could raise statin exposure. Clinically significant myopathy from this pairing is not well established and the effect is probably small.
What this interaction means in plain words
Pitavastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pitavastatin belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of pitavastatin by telmisartan, modestly increasing statin plasma levels.
What to do
No dose change is generally needed; counsel the patient to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Pitavastatin with Telmisartan-amlodipine?
MediHelp rates the interaction as minor. Pitavastatin and Telmisartan-amlodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan has been described as an OATP1B1 inhibitor in vitro, which could raise statin exposure. Clinically significant myopathy from this pairing is not well established and the effect is probably small.
How serious is the interaction between Pitavastatin and Telmisartan-amlodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; counsel the patient to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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