Drug interactions
Ponatinib + Rifaximin
Severity: Minor
Ponatinib and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib may inhibit P-glycoprotein and could increase systemic rifaximin levels. Because rifaximin absorption is normally minimal, the clinical effect is likely small except in hepatic impairment.
What this interaction means in plain words
Ponatinib and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ponatinib belongs to Oncology; Rifaximin belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by ponatinib reduces efflux of rifaximin.
What to do
No routine dose change is needed. Monitor for rifaximin adverse effects in patients with severe hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Ponatinib
Frequently asked questions
Can I take Ponatinib with Rifaximin?
MediHelp rates the interaction as minor. Ponatinib and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib may inhibit P-glycoprotein and could increase systemic rifaximin levels. Because rifaximin absorption is normally minimal, the clinical effect is likely small except in hepatic impairment.
How serious is the interaction between Ponatinib and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for rifaximin adverse effects in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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