Drug interactions
Prazosin + Quinapril
Severity: Moderate
Prazosin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to prazosin, or the reverse, can increase the blood pressure fall, especially after the first doses. Symptomatic hypotension and syncope may occur.
What this interaction means in plain words
Prazosin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from alpha-1 blockade and inhibition of angiotensin II formation.
What to do
Start the new drug at a low dose, ideally at bedtime, and monitor blood pressure. Reduce the dose of one drug if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Quinapril?
MediHelp rates the interaction as moderate. Prazosin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to prazosin, or the reverse, can increase the blood pressure fall, especially after the first doses. Symptomatic hypotension and syncope may occur.
How serious is the interaction between Prazosin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the new drug at a low dose, ideally at bedtime, and monitor blood pressure. Reduce the dose of one drug if hypotension develops.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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