Drug interactions
prazosin + sildenafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Symptomatic hypotension risk.
Mechanism of action
Additive vasodilation.
Clinical management
Separate dosing/lowest doses or avoid.
Drug reference
References
Frequently asked questions
Can I take prazosin with sildenafil?
The interaction is rated: Major. Symptomatic hypotension risk.
How serious is the interaction between prazosin and sildenafil?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between prazosin and sildenafil managed?
Separate dosing/lowest doses or avoid.
Why do prazosin and sildenafil interact?
Additive vasodilation.
Full monographs, dosing and an interaction checker in the MediHelp app
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