Drug interactions
Prazosin + Yohimbe
Severity: Moderate
Prazosin and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine in yohimbe is an alpha-2 antagonist that can raise sympathetic outflow and blood pressure, which opposes prazosin's alpha-1 blockade. Effects are unpredictable and the content of yohimbe products varies, so antihypertensive control may be lost or blood pressure may be erratic.
What this interaction means in plain words
Prazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic actions: alpha-2 antagonism by yohimbine increases noradrenaline release, counteracting alpha-1 blockade.
What to do
Advise patients to avoid yohimbe products. Monitor blood pressure and heart rate if use cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Yohimbe?
MediHelp rates the interaction as moderate. Prazosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine in yohimbe is an alpha-2 antagonist that can raise sympathetic outflow and blood pressure, which opposes prazosin's alpha-1 blockade. Effects are unpredictable and the content of yohimbe products varies, so antihypertensive control may be lost or blood pressure may be erratic.
How serious is the interaction between Prazosin and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products. Monitor blood pressure and heart rate if use cannot be stopped.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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