Drug interactions
Prazosin + Zotepine
Severity: Moderate
Prazosin and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-1 adrenergic antagonist activity, which adds to the vasodilating effect of prazosin. This can lead to orthostatic hypotension, dizziness, syncope and reflex tachycardia.
What this interaction means in plain words
Prazosin and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive alpha-1 adrenergic receptor blockade.
What to do
Monitor standing blood pressure and start with low doses. Reduce the dose of prazosin or zotepine if postural symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Zotepine?
MediHelp rates the interaction as moderate. Prazosin and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-1 adrenergic antagonist activity, which adds to the vasodilating effect of prazosin. This can lead to orthostatic hypotension, dizziness, syncope and reflex tachycardia.
How serious is the interaction between Prazosin and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor standing blood pressure and start with low doses. Reduce the dose of prazosin or zotepine if postural symptoms occur.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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