Drug interactions
Procainamide + Tenofovir disoproxil
Severity: Moderate
Procainamide and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by active renal tubular secretion, so competition may increase levels of either drug. Procainamide accumulation can cause QT prolongation, arrhythmias and lupus-like effects.
What this interaction means in plain words
Procainamide and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion via organic cation transporters and related pathways.
What to do
Monitor ECG and procainamide and NAPA levels, and watch renal function and tenofovir adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Procainamide with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Procainamide and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by active renal tubular secretion, so competition may increase levels of either drug. Procainamide accumulation can cause QT prolongation, arrhythmias and lupus-like effects.
How serious is the interaction between Procainamide and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and procainamide and NAPA levels, and watch renal function and tenofovir adverse effects.
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