Drug interactions
Progesterone micronized + Rifaximin
Severity: Minor
Progesterone micronized and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone shows P-glycoprotein inhibitory activity in vitro and might slightly raise rifaximin absorption. Given rifaximin's low systemic exposure, clinical significance is expected to be minimal.
What this interaction means in plain words
Progesterone micronized and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Potential P-glycoprotein inhibition by progesterone decreases rifaximin efflux.
What to do
No action is generally required. Be aware of this effect if rifaximin tolerability problems arise in hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
- Dronedarone + Rifaximin Moderate
Frequently asked questions
Can I take Progesterone micronized with Rifaximin?
MediHelp rates the interaction as minor. Progesterone micronized and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progesterone shows P-glycoprotein inhibitory activity in vitro and might slightly raise rifaximin absorption. Given rifaximin's low systemic exposure, clinical significance is expected to be minimal.
How serious is the interaction between Progesterone micronized and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Be aware of this effect if rifaximin tolerability problems arise in hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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