Drug interactions
Pyridoxine + Theophylline
Severity: Minor
Pyridoxine and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Theophylline can lower plasma pyridoxal 5-phosphate levels, and prolonged use may contribute to vitamin B6 depletion. This is of limited clinical significance in most patients.
What this interaction means in plain words
Pyridoxine and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theophylline inhibits pyridoxal kinase, reducing formation of active pyridoxal 5-phosphate.
What to do
No routine action is needed; consider assessing vitamin B6 status if neuropathy or deficiency symptoms develop on long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Pyridoxine with Theophylline?
MediHelp rates the interaction as minor. Pyridoxine and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Theophylline can lower plasma pyridoxal 5-phosphate levels, and prolonged use may contribute to vitamin B6 depletion. This is of limited clinical significance in most patients.
How serious is the interaction between Pyridoxine and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider assessing vitamin B6 status if neuropathy or deficiency symptoms develop on long-term therapy.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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