Drug interactions
Quazepam + Zolpidem
Severity: Major
Quazepam and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining zolpidem with the benzodiazepine quazepam adds sedative-hypnotic effects, raising the risk of excessive sedation, falls, amnesia and respiratory depression. Quazepam has long-acting active metabolites, so effects can persist into the next day.
What this interaction means in plain words
Quazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS depression from two positive GABA-A receptor modulators.
What to do
Avoid using two hypnotics together; if unavoidable, use the lowest doses for the shortest time and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Quazepam with Zolpidem?
MediHelp rates the interaction as major. Quazepam and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining zolpidem with the benzodiazepine quazepam adds sedative-hypnotic effects, raising the risk of excessive sedation, falls, amnesia and respiratory depression. Quazepam has long-acting active metabolites, so effects can persist into the next day.
How serious is the interaction between Quazepam and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two hypnotics together; if unavoidable, use the lowest doses for the shortest time and monitor for sedation and respiratory depression.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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