Drug interactions
Quinupristin / dalfopristin + Rabeprazole
Severity: Minor
Quinupristin / dalfopristin and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, but rabeprazole relies little on this pathway. A meaningful rise in rabeprazole exposure is not expected, and the drug is given intravenously for serious infections.
What this interaction means in plain words
Quinupristin / dalfopristin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition may slightly reduce the minor oxidative clearance of rabeprazole.
What to do
No dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinupristin / dalfopristin and Rabeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Quinupristin / dalfopristin with Rabeprazole?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4, but rabeprazole relies little on this pathway. A meaningful rise in rabeprazole exposure is not expected, and the drug is given intravenously for serious infections.
How serious is the interaction between Quinupristin / dalfopristin and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
