Drug interactions
Quinupristin / dalfopristin + Theophylline
Severity: Minor
Quinupristin / dalfopristin and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, but theophylline is mainly cleared by CYP1A2, so a clinically significant effect is unlikely.
What this interaction means in plain words
Quinupristin / dalfopristin and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition may slightly reduce a minor theophylline elimination pathway.
What to do
No routine adjustment is needed; check theophylline levels if signs of toxicity develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Quinupristin / dalfopristin with Theophylline?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4, but theophylline is mainly cleared by CYP1A2, so a clinically significant effect is unlikely.
How serious is the interaction between Quinupristin / dalfopristin and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check theophylline levels if signs of toxicity develop.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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