Drug interactions
Quinupristin / dalfopristin + Zaleplon
Severity: Minor
Quinupristin / dalfopristin and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and might raise zaleplon concentrations slightly. The effect is expected to be small, since zaleplon is cleared mostly by aldehyde oxidase.
What this interaction means in plain words
Quinupristin / dalfopristin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing a minor zaleplon elimination pathway.
What to do
No dose change is routinely needed; monitor for excess sedation during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Quinupristin / dalfopristin with Zaleplon?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and might raise zaleplon concentrations slightly. The effect is expected to be small, since zaleplon is cleared mostly by aldehyde oxidase.
How serious is the interaction between Quinupristin / dalfopristin and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for excess sedation during therapy.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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