Drug interactions
Rabeprazole + Saquinavir
Severity: Moderate
Rabeprazole and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole has been shown to raise saquinavir exposure, and a similar effect is considered possible with other PPIs. Higher saquinavir concentrations may increase the risk of QT and PR prolongation and other adverse effects.
What this interaction means in plain words
Rabeprazole and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probably increased saquinavir absorption through raised gastric pH or altered transport, but the mechanism is not firmly established.
What to do
Monitor for saquinavir toxicity and obtain an ECG at baseline and during therapy. Follow the labeling for saquinavir/ritonavir and the PPI.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Rabeprazole with Saquinavir?
MediHelp rates the interaction as moderate. Rabeprazole and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole has been shown to raise saquinavir exposure, and a similar effect is considered possible with other PPIs. Higher saquinavir concentrations may increase the risk of QT and PR prolongation and other adverse effects.
How serious is the interaction between Rabeprazole and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saquinavir toxicity and obtain an ECG at baseline and during therapy. Follow the labeling for saquinavir/ritonavir and the PPI.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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