Drug interactions
Rabeprazole + Thyroid desiccated
Severity: Moderate
Rabeprazole and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced gastric acidity may impair absorption of oral thyroid hormone, and proton pump inhibitors can raise TSH in some patients. Evidence is conflicting and effects are usually modest.
What this interaction means in plain words
Rabeprazole and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH may reduce dissolution and absorption of the oral thyroid hormone.
What to do
Check TSH about 6 to 8 weeks after starting or stopping rabeprazole and adjust the thyroid dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Rabeprazole with Thyroid desiccated?
MediHelp rates the interaction as moderate. Rabeprazole and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reduced gastric acidity may impair absorption of oral thyroid hormone, and proton pump inhibitors can raise TSH in some patients. Evidence is conflicting and effects are usually modest.
How serious is the interaction between Rabeprazole and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH about 6 to 8 weeks after starting or stopping rabeprazole and adjust the thyroid dose as needed.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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