Drug interactions
Remifentanil + Sumatriptan intranasal
Severity: Moderate
Remifentanil and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and triptans both have the potential to raise serotonergic activity, so serotonin syndrome is a theoretical concern. The reported risk with remifentanil is low.
What this interaction means in plain words
Remifentanil and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects between an opioid and a 5-HT1B/1D agonist.
What to do
Monitor for signs of serotonin syndrome such as agitation, tremor, clonus and fever. Stop the drugs and give supportive care if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Remifentanil and Sumatriptan intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Remifentanil with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Remifentanil and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and triptans both have the potential to raise serotonergic activity, so serotonin syndrome is a theoretical concern. The reported risk with remifentanil is low.
How serious is the interaction between Remifentanil and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome such as agitation, tremor, clonus and fever. Stop the drugs and give supportive care if symptoms occur.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
